Sodium Hydroxide → 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-3-butenoic acid

HRID 251568ノート

反応式

HRID 251568 の反応式
[CH3:1][C:2]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH2:14][C:15]([O:17]CC)=[O:16])[CH:9]=[CH:10][CH:11]=1.[OH-].[Na+]>C(O)C>[CH3:24][C:20]1[CH:21]=[CH:22][CH:23]=[C:2]([CH3:1])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH2:14][C:15]([OH:17])=[O:16])[CH:9]=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 67274119Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-3-butenoate

生成物 1

HCID 672736064-(3-(2,6-Dimethylbenzyloxy)phenyl)-3-butenoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-3-butenoate (Step F) in abs ethanol at low temp, add aqueous sodium hydroxide, after an hour, concentrate and purify by flash chromatography on silica gel column (chloroform:methanol 95:5 spiked with acetic acid).

後処理

  1. waitafter an hour
  2. concentrationconcentrate
  3. custompurify by flash chromatography on silica gel column (chloroform:methanol 95:5 spiked with acetic acid)

出典と根拠

ORDレコード
ord-d280e09475f14a83b1ab8d9b48d1297f
出典データセット
uspto-grants-2011_01
特許番号
US07863475B2

反応ノート

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