Sodium Hydroxide → 1-Benzyl-4-hydroxypiperidine-4-carboxamide
反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([OH:16])([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:17].[Na+]>OS(O)(=O)=O.O>[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]([OH:16])([C:14]([NH2:15])=[O:17])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
1-Benzyl-4-hydroxy-piperidine-4-carbonitrile (5 g, 23.12 mmol) is dissolved in a mixture of H2SO4 (18 mL) and H2O (2 mL) at 0° C. The mixture is warmed to room temperature for 14 hours, transferred into cold 2 N NaOH and adjusted to pH>8. The solid is filtered and washed with H2O, and dried over sodium sulfate to give the crude product.
後処理
- filtrationThe solid is filtered
- washwashed with H2O
- dry with materialdried over sodium sulfate
出典と根拠
- ORDレコード
- ord-98be93cc291c422482bdd7f488f3f57f
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863454B2
反応ノート
読み込み中…