Ethyl Acetate → HCID 22062410、化合物

HRID 251731

反応式

HRID 251731 の反応式
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)=[O:4].[N-:15]=[N+:16]=[N-:17].[Na+].CCOC(C)=O>CC(C)=O>[N:15]([CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)=[O:4])=[N+:16]=[N-:17]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 33557Sodium AzideHCID 691792-Bromo-2'-acetonaphthone

生成物 1

HCID 22062410HCID 22062410、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To 2-bromo-1-(2-naphthyl)ethanone in acetone was added NaN3 (1 eq.) and the mixture was stirred at RT for 24 h. EtOAc was added (10 vol.) and the mixture was filtered. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography on silica eluting with 10% EtOAc/Petroleum ether to obtain the product as a white solid. 1H NMR (300 MHz, CDCl3) δ: 8.39 (1H, s), 8.02-7.82 (4H, m), 7.69-7.50 (2H, m), 4.68 (2H, s). MS (ES) C12H9N3O requires: 211, found: 212 (M+H)+.

後処理

  1. filtrationthe mixture was filtered
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe residue was purified by flash chromatography on silica eluting with 10% EtOAc/Petroleum ether

出典と根拠

ORDレコード
ord-d7ccc8a8dc384a5893b3d6b1cf413a82
出典データセット
uspto-grants-2011_01
特許番号
US07863294B2

関連ノート

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