Phenacyl bromide → 6-Bromo-2-phenylimidazo[1,2-a]pyridine
反応式
[CH2:1](Br)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=O.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][N:13]=1.C(=O)([O-])O.[Na+]>C(O)C>[Br:18][C:15]1[CH:16]=[CH:17][C:12]2[N:13]([CH:1]=[C:2]([C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[N:11]=2)[CH:14]=1参加物
5
実験手順
Dissolving 5.8 g (29 mmol) of phenacyl bromide and 5.0 g (29 mmol) of 2-amino-5-bromopyridine into 50 milliliter of ethanol, adding 3.6 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 6 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and ethanol, thereby obtaining 6.4 g of 6-bromo-2-phenyl-imidazo [1,2-a] pyridine (yield: 81%).
後処理
- temperatureunder heating for 6 hours
- customAfter completion of the reaction, separation
- filtrationwith filtration
- washresultant crystals were washed with water and ethanol
出典と根拠
- ORDレコード
- ord-ec6f08cadf0f45ebbda18c1b1ca535b5
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07867629B2
反応ノート
読み込み中…