6-Amino-3-chloropyridazine → 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile

HRID 251805

反応式

HRID 251805 の反応式
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])=O.[Cl:13][C:14]1[N:19]=[N:18][C:17]([NH2:20])=[CH:16][CH:15]=1>CCO>[Cl:13][C:14]1[CH:15]=[CH:16][C:17]2[N:18]([CH:2]=[C:3]([C:5]3[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=3)[C:8]#[N:9])[N:20]=2)[N:19]=1

参加物

4

反応物 2

HCID 216436-Amino-3-chloropyridazineHCID 27358673-(2-Bromoacetyl)benzonitrile

生成物 1

HCID 468355643-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile収率 50%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1 mmol 3-(2-bromoacetyl)benzonitrile and 1 mmol 6-chloropyridazin-3-amine in 10 ml EtOH were heated to reflux for 12 h, then cooled to room temperature. The orange-red precipitate was collected by filtration, washed with cold EtOH, and air-dried to give the 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (125 mg, 50%).

後処理

  1. temperatureto reflux for 12 h
  2. filtrationThe orange-red precipitate was collected by filtration
  3. washwashed with cold EtOH
  4. customair-dried

出典と根拠

ORDレコード
ord-8b23bb73b09a4ae99af5a05f93b29787
出典データセット
uspto-grants-2011_01
特許番号
US07868001B2

関連ノート

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