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3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 46835564 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 生成物 | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 53439477 | — |
反応手順
2.5 mg 10% Pd-C were added to the solution of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (50 mg, 0.2 mmol) in THF/MeOH 25 ml. The reaction mixture was stirred vigorously at room temperature for 4 h under hydrogen and the Pd—C was then removed. The filtrate was concentrated in vacuo to give the 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile as a yellow-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07868001B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-ab15fbc426654cfabef2405f47f2265e |
| 出典メモ | uspto-grants-2011_01 |