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Isocyanatocyclopropane → HCID 66861132、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isocyanatocyclopropane | HCID 637659 | — |
| 反応物 | 1-Cyclopropyl-N-(2,4-dichlorobenzyl)-7-[(3RS,5SR)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide | HCID 66859962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 66861132 | HCID 66861132 | — |
反応手順
30 μl (24.3 mg, 0.29 mmol) of cyclopropylisocyanate are dissolved in dichloromethan, 80.0 mg (0.146 mmol) of the compound of Example 12 are added and the mixture is stirred over night at room temperature. For the work-up the solvent is removed completely and after fine purification by preparative RP-HPLC (Method 6) 55 mg of the target compound are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07867992B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-d9c6184ee2354d53a2328dc7ba903420 |
| 出典メモ | uspto-grants-2011_01 |