HRID251865

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID637659

isocyanatocyclopropane

C4H5NO

结构：COc1c(N2CC(C)NC(C)C2)c(F)cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3Cl)cn(C3CC3)c12

HCID66859962

未命名化合物

PRODUCTS

生成物

结构：COc1c(N2CC(C)N(C(=O)NC3CC3)C(C)C2)c(F)cc2c(=O)c(C(=O)NCc3ccc(Cl)cc3Cl)cn(C3CC3)c12

HCID66861132

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

30 μl (24.3 mg, 0.29 mmol) of cyclopropylisocyanate are dissolved in dichloromethan, 80.0 mg (0.146 mmol) of the compound of Example 12 are added and the mixture is stirred over night at room temperature. For the work-up the solvent is removed completely and after fine purification by preparative RP-HPLC (Method 6) 55 mg of the target compound are obtained.

WORKUP

后处理

customFor the work-up the solvent is removed completely
customafter fine purification by preparative RP-HPLC (Method 6) 55 mg of the target compound
customare obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9c6184ee2354d53a2328dc7ba903420
来源数据集: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07867992B2
来源说明: uspto-grants-2011_01

反应 SMILES

[CH:1]1([N:4]=[C:5]=[O:6])[CH2:3][CH2:2]1.[CH:7]1([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:30])=[C:17]([N:22]4[CH2:27][CH:26]([CH3:28])[NH:25][CH:24]([CH3:29])[CH2:23]4)[C:18]=3[O:20][CH3:21])[C:13](=[O:31])[C:12]([C:32]([NH:34][CH2:35][C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][C:37]=3[Cl:43])=[O:33])=[CH:11]2)[CH2:9][CH2:8]1>ClCCl>[CH:7]1([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:30])=[C:17]([N:22]4[CH2:23][CH:24]([CH3:29])[N:25]([C:5]([NH:4][CH:1]5[CH2:3][CH2:2]5)=[O:6])[CH:26]([CH3:28])[CH2:27]4)[C:18]=3[O:20][CH3:21])[C:13](=[O:31])[C:12]([C:32]([NH:34][CH2:35][C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][C:37]=3[Cl:43])=[O:33])=[CH:11]2)[CH2:9][CH2:8]1