Pyrazole → N,N-dimethyl-1H-pyrazole-1-sulfonamide

HRID 251912

反応式

HRID 251912 の反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.C1(C)C=CC=CC=1.[CH3:13][N:14]([CH3:19])[S:15](Cl)(=[O:17])=[O:16]>C(N(CC)CC)C>[CH3:13][N:14]([CH3:19])[S:15]([N:1]1[CH:5]=[CH:4][CH:3]=[N:2]1)(=[O:17])=[O:16]

参加物

5

反応物 3

HCID 1048PyrazoleHCID 1140TolueneHCID 83372Dimethylsulphamoyl chloride

生成物 1

HCID 10954038N,N-dimethyl-1H-pyrazole-1-sulfonamide

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To a mixture of 15 g of pyrazole and 200 ml of toluene was added dropwise 23.7 ml of dimethylsulfamoyl chloride at room temperature. Then, 40 ml of triethylamine was added to the mixture, and the mixture was stirred at room temperature for 18 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to obtain 17.6 g of N,N-dimethyl-1H-pyrazole-1-sulfonamide of the formula:

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-14e014218f524dfa98603c57aeceaf44
出典データセット
uspto-grants-2011_01
特許番号
US07867949B2

関連ノート

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