Ethanol → Ethyl 2-methoxyimino-5-methyl-4-oxohexanoate

HRID 251951ノート

反応式

HRID 251951 の反応式
[OH:1][C:2]([CH:11]([CH3:13])[CH3:12])=[CH:3][C:4](=O)[C:5]([O:7][CH2:8][CH3:9])=[O:6].Cl.[CH3:15][O:16][NH2:17].C(O)C>C(OCC)(=O)C>[CH3:15][O:16][N:17]=[C:4]([CH2:3][C:2](=[O:1])[CH:11]([CH3:13])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

5

反応物 3

HCID 702EthanolHCID 521874O-Methylhydroxylamine hydrochlorideHCID 178473097HCID 178473097、化合物

生成物 1

HCID 86632548Ethyl 2-methoxyimino-5-methyl-4-oxohexanoate収率 92%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 5.0 g of ethyl 4-hydroxy-5-methyl-2-oxo-3-hexenoate, 2.46 g of O-methylhydroxylamine hydrochloride and 10 ml of ethanol was stirred at room temperature for 6 hours. After ethyl acetate was poured into the reaction mixture, the organic layer was washed with water and an aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 5.32 g of ethyl 2-methoxyimino-5-methyl-4-oxohexanoate of the formula:

後処理

  1. washthe organic layer was washed with water
  2. dry with materialan aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-4ac0103fd2954689a164b080008c8f22
出典データセット
uspto-grants-2011_01
特許番号
US07867949B2

反応ノート

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