2-Bromo-4-chlorobenzoic acid → (2-Bromo-4-chlorophenyl)methanol
反応式
B.C1COCC1.[Br:7][C:8]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:9]=1[C:10](O)=[O:11]>C1COCC1>[Br:7][C:8]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:9]=1[CH2:10][OH:11]参加物
4
実験手順
Add borane-THF (1 M in THF, 3.2 mL) complex dropwise to an ice-cooled solution of 2-bromo-4-chlorobenzoic acid (500 mg, 2.1 mmol) in THF (2 mL). Remove the cooling bath and stir overnight. Slowly add water (1 mL) and solid sodium carbonate. Stir 1 h. Filter and wash solids with THF. Chromatograph on silica gel, eluting with 0:100 to 30:70 ethyl acetate:dichloromethane to give 2-bromo-4-chlorobenzyl alcohol as a white solid (378 mg, 80%).
後処理
- customRemove the cooling bath
- stirringStir 1 h
- filtrationFilter
- washwash solids with THF
- washChromatograph on silica gel, eluting with 0:100 to 30:70 ethyl acetate
出典と根拠
- ORDレコード
- ord-99fc7593d3714863940340fb8582927e
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07868014B2
反応ノート
読み込み中…