2-Bromo-3-methylthiophene → 2-(2-Methoxy-ethyl)-3-methyl-thiophene

HRID 252262

反応式

HRID 252262 の反応式
Br[C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH3:7].[CH3:8][O:9][CH2:10][CH2:11]OS(C1C=CC(C)=CC=1)(=O)=O>>[CH3:8][O:9][CH2:10][CH2:11][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH3:7]

参加物

3

反応物 2

HCID 843142-Bromo-3-methylthiopheneHCID 86977Ethanol, 2-methoxy-, 1-(4-methylbenzenesulfonate)

生成物 1

HCID 668571532-(2-Methoxy-ethyl)-3-methyl-thiophene

実験手順

This compound was prepared analogous to Example 61, starting with 2-bromo-3-methylthiophene (1.5 g, 8.5 mmol) and toluene-4-sulfonic acid 2-methoxy-ethyl ester (2.9 g, 12.7 mmol, 1.5 equiv.) The crude product was purified on silica gel with eluent n-heptane and tert.butylmethyl ether. The title compound was obtained as a light yellow oil, 490 mg. GC-MS (EI): M=156

後処理

  1. customThis compound was prepared analogous to Example 61
  2. customwas purified on silica gel with eluent n-heptane and tert.butylmethyl ether

出典と根拠

ORDレコード
ord-6731e61c88124716ad4a635d0b337a3d
出典データセット
uspto-grants-2011_01
特許番号
US07868030B2

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