Potassium Carbonate → 1-(2-Amino-3-nitrophenoxy)-2,3-epoxypropane

HRID 25236

反応式

HRID 25236 の反応式
S(C1C=CC(C)=CC=1)(O[CH2:5][CH:6]1[O:8][CH2:7]1)(=O)=O.[NH2:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[CH:19][C:18]=1[OH:26].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[NH2:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[CH:19][C:18]=1[O:26][CH2:5][CH:6]1[O:8][CH2:7]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 160868Glycidyl tosylateHCID 41154952-Amino-3-Nitrophenol

生成物 1

HCID 113448381-(2-Amino-3-nitrophenoxy)-2,3-epoxypropane

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

21.7 g (0.095 mol) of glycidyl tosylate, 10 g (0.0475 mol) of 2-amino-3-nitrophenol and 6.5 g of crushed K2CO3 are mixed in acetone and the mixture is heated at reflux for 18 hours. The mixture is filtered and the solvent is evaporated under reduced pressure. The crude reaction product is purified by flash chromatography, elution being carried out with a 9/1 hexane/ethyl acetate mixture. The title compound is obtained. M.p.: 7°-78° C.

後処理

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 18 hours
  3. filtrationThe mixture is filtered
  4. customthe solvent is evaporated under reduced pressure
  5. customThe crude reaction product
  6. customis purified by flash chromatography, elution

出典と根拠

ORDレコード
ord-e07988679b094e7aa963e37ef2a90aed
出典データセット
uspto-grants-2005_02
特許番号
US06858629B1

関連ノート

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