Methanol → (4,5-Difluoro-2-nitrophenyl)methanol
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]([N+:12]([O-:14])=[O:13])=[CH:9][C:10]=1[F:11])[C:5](O)=[O:6].CO>C1COCC1>[F:11][C:10]1[C:2]([F:1])=[CH:3][C:4]([CH2:5][OH:6])=[C:8]([N+:12]([O-:14])=[O:13])[CH:9]=1参加物
4
実験手順
To a solution of 3,4-difluoro-6-nitrobenzoic acid (3.05 g, 15 mmol) in THF (20 mL) was added BH3 THF (30 mL). The resulting mixture was stirred at room temperature for 2 h and then at 50° C. for 5 h. The resulting mixture was then cooled to room temperature, and methanol (20 mL) was added slowly. The resulting mixture was concentrated, and the residue was treated with methanol twice more, to yield a yellow solid.
後処理
- waitat 50° C. for 5 h
- temperatureThe resulting mixture was then cooled to room temperature
- concentrationThe resulting mixture was concentrated
- additionthe residue was treated with methanol twice more
- customto yield a yellow solid
出典と根拠
- ORDレコード
- ord-6848fa55f13349e3a09172e81b693666
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07868022B2
反応ノート
読み込み中…