Nitric Acid → 2-Bromo-1,3-dimethyl-4-nitrobenzene

HRID 25272

反応式

HRID 25272 の反応式
[N+:1]([O-:4])(O)=[O:2].[Br:5][C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:13]>C(O)(=O)C>[CH3:13][C:7]1[C:8]([N+:1]([O-:4])=[O:2])=[CH:9][CH:10]=[C:11]([CH3:12])[C:6]=1[Br:5]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 684712-Bromo-m-xylene

生成物 1

HCID 123959052-Bromo-1,3-dimethyl-4-nitrobenzene

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Fuming nitric acid (>90% yellow fuming HNO3) is slowly added to a solution of 2-bromo-m-xylene (20 g, 150 mmol) in acetic acid (100 ml) cooled in an ice bath (above freezing point). The resulting mixture is allowed to warm to room temperature, stirred for 1 hour, and heated at 80° C. for 2 hours or until the reaction is shown to be complete by GC/MS analysis following micro-scale base work-up. The reaction mixture is cooled to room temperature and poured into ice/water with stirring. The resulting yellow precipitates are collected by suction filtration and air dried to obtain 2,6-dimethyl-3-nitrobromobenzene.

後処理

  1. temperaturecooled in an ice bath (above freezing point)
  2. temperatureheated at 80° C. for 2 hours or until the reaction
  3. temperatureThe reaction mixture is cooled to room temperature
  4. stirringwith stirring
  5. customThe resulting yellow precipitates
  6. filtrationare collected by suction filtration and air
  7. customdried

出典と根拠

ORDレコード
ord-be524cb8b1a6445599b71a2c69566762
出典データセット
uspto-grants-2005_02
特許番号
US06858637B2

関連ノート

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