Methyl p-toluenesulfonate → HCID 178503586、化合物
反応式
[CH3:1][S:2][C:3]1[S:4][C:5]2[CH:6]=[N:7][CH:8]=[CH:9][C:10]=2[N:11]=1.[S:12]([C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)([O:15][CH3:16])(=[O:14])=[O:13]>C(OCC)(=O)C>[S:12]([C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)([O-:15])(=[O:14])=[O:13].[CH3:16][N:7]1[CH:8]=[CH:9][C:10]2=[NH+:11][CH:3]([S:2][CH3:1])[S:4][C:5]2=[CH:6]1参加物
4
反応条件
- 温度
- 120 °C
実験手順
A mixture of 0.127 g of 2-methylthiothiazolo[5,4-c]pyridine (from methylation of thiazolo[5,4-c]pyridine-2(1H)-thione with potassium carbonate and methyl iodide) and 0.143 g methyl tosylate is heated at 120° C. for one hour. Ethyl acetate (8 mL) is added, the mixture is stirred for 30 minutes, and Compound 6 is isolated by suction filtration.