Tetrahydrofuran → N-(3-methyl-benzylidene)-N'-[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethyl)-pyrimidin-4-yl]-hydrazine
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][CH:29]=1)[CH:5]=[N:6][NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:11]=[C:10]([CH2:20]COS(C)(=O)=O)[N:9]=1.[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1.O1CCC[CH2:37]1>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][CH:29]=1)[CH:5]=[N:6][NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[N:11]=[C:10]([CH2:20][CH2:37][N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[N:9]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
Compound 95, methanesulfonic acid 2-{4-[N′-(3-methyl-benzylidene)-hydrazino]-6-morpholin-4-yl-pyrimidin-2-yl}-ethyl ester (104 mg., 0.25 mmol) was dissolved in tetrahydrofuran (4 mL). To the reaction mixture was added morpholine (43 mg., 0.5 mmol) and the vessel was sealed and heated at 80° C. for sixteen hours. The solvent was removed under reduced pressure and the crude oil was purified by column chromatography to give Compound 94, N-(3-methyl-benzylidene)-N′-[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethyl)-pyrimidin-4-yl]-hydrazine (52 mg., 0.13 mmol).