Sodium borohydride → 3-Phenylcyclopentan-1-ol

HRID 253090ノート

反応式

HRID 253090 の反応式
[C:1]1([CH:7]2[CH2:11][CH2:10][C:9](=[O:12])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>CO>[C:1]1([CH:7]2[CH2:11][CH2:10][CH:9]([OH:12])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 111374333-Phenylcyclopentan-1-one

生成物 1

HCID 2756203-Phenylcyclopentan-1-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3-phenylcyclopentanone (1.3 g, 8.12 mmol) and NaBH4 (0.61 g, 16.24 mmol) in methanol (15 mL) was stirred at room temperature for 1 h. The mixture was concentrated, dissolved in CH2Cl2, washed with 10% HCl, brine, dried over MgSO4 and concentrated to afford the title compound as a white solid. MS m/z: 163 (M+1).

後処理

  1. concentrationThe mixture was concentrated
  2. dissolutiondissolved in CH2Cl2
  3. washwashed with 10% HCl, brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-075fccb3eb414be4bd08b5e805b4e1dd
出典データセット
uspto-grants-2011_01
特許番号
US07872009B2

反応ノート

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