Dimethylformamide → 2-(3',4'-dimethylbiphenyl-3-yl)-9-hydroxyl-3H-naphtho[1,2-d]imidazole-7-sulfonyl chloride

HRID 25319ノート

反応式

HRID 25319 の反応式
[ClH:1].[CH3:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[NH:17][C:18]4[CH:28]=[CH:27][C:26]5[C:21](=[C:22]([OH:33])[CH:23]=[C:24]([S:29](O)(=[O:31])=[O:30])[CH:25]=5)[C:19]=4[N:20]=3)[CH:11]=2)[CH:6]=[CH:7][C:8]=1[CH3:9].CN(C)C=O>S(Cl)(Cl)=O>[CH3:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[NH:17][C:18]4[CH:28]=[CH:27][C:26]5[C:21](=[C:22]([OH:33])[CH:23]=[C:24]([S:29]([Cl:1])(=[O:31])=[O:30])[CH:25]=5)[C:19]=4[N:20]=3)[CH:11]=2)[CH:6]=[CH:7][C:8]=1[CH3:9]

参加物

4

反応物 2

HCID 6228DimethylformamideHCID 101628942-(3',4'-dimethylbiphenyl-3-yl)-9-hydroxyl-3H-naphtho[1,2-d]imidazole-7-sulfonic acid hydrochloride

生成物 1

HCID 225666742-(3',4'-dimethylbiphenyl-3-yl)-9-hydroxyl-3H-naphtho[1,2-d]imidazole-7-sulfonyl chloride

試薬・触媒・溶媒 1

HCID 24386Thionyl Chloride溶媒

反応条件

温度
60 °C

実験手順

2-(3′,4′-dimethylbiphenyl-3-yl)-9-hydroxyl-3H-naphtho[1,2-d]imidazole-7-sulfonic acid hydrochloride(0.08 g, 0.18 mmol) was suspended in 1 ml thionyl chloride containing catalytic amount of N,N-dimethylformamide. The reaction mixture was heated to 60° C. for 3 hours then was concentrated to dryness to give 2-(3′,4′-dimethylbiphenyl-3-yl)-9-hydroxyl-3H-naphtho[1,2-d]imidazole-7-sulfonyl chloride.

後処理

  1. concentrationthen was concentrated to dryness

出典と根拠

ORDレコード
ord-ded3e96cbac64937a118c71ce87519d4
出典データセット
uspto-grants-2005_02
特許番号
US06858630B2

反応ノート

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