Hydrochloric Acid → HCID 57434496、化合物

HRID 253334

反応式

HRID 253334 の反応式
[ClH:1].C(O)C.O[N:6]=[C:7]([C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[C:8]([O:10][CH2:11][CH3:12])=[O:9]>[Pd]>[ClH:1].[NH2:6][CH:7]([C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[C:8]([O:10][CH2:11][CH3:12])=[O:9]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178472908HCID 178472908、化合物

生成物 1

HCID 57434496HCID 57434496、化合物

試薬・触媒・溶媒 1

HCID 23938Palladium溶媒

実験手順

10 g of HCl are introduced into 200 ml of ethanol. 46 g of ethyl 2-hydroxyimino-4-methyl-3-oxopentanoate are dissolved in this mixture, 5 g of Pd (10% on carbon) are added and the mixture is stirred under an atmosphere of hydrogen (5 bar) for 8 hours. The reaction mixture is filtered through Celite and the solvent is removed under reduced pressure. This gives 45 g of ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride as a white solid. C8H15NO3*HCl (209.5), MS (ESI)=188 (M+H+).

後処理

  1. additionare added
  2. filtrationThe reaction mixture is filtered through Celite
  3. customthe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-8e2d217522d847769669ae1246a0eb9c
出典データセット
uspto-grants-2011_01
特許番号
US07872034B2

関連ノート

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