1H-Pyrrolo(2,3-b)pyridine → 7-aza-1H-indole N-oxide

HRID 253468ノート

反応式

HRID 253468 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.C1C=C(Cl)C=C(C(OO)=[O:18])C=1>C(OCC)C>[NH+:1]1([O-:18])[C:9]2=[N:8][CH:7]=[CH:6][CH:5]=[C:4]2[CH:3]=[CH:2]1

参加物

4

反応物 2

HCID 92221H-Pyrrolo(2,3-b)pyridineHCID 70297m-Chloroperbenzoic acid

生成物 1

HCID 219590977-aza-1H-indole N-oxide収率 125%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To 1H-pyrrolo[2,3-b]pyridine (6, 3.0 g, 25.3 mmol) dissolved in 175 mL of diethyl ether was added m-CPBA (1.5 equiv) in portions over 30 minutes with vigorous stirring. The solution turned yellow, and precipitates formed. After two hours the solid was collected, washed with 2×50 mL of ether, and recrystallized from acetone:ether. Yield was approximately 125% due to contaminating acid. This crude material was carried through to the next step.

後処理

  1. customprecipitates
  2. customformed
  3. customAfter two hours the solid was collected
  4. washwashed with 2×50 mL of ether
  5. customrecrystallized from acetone

出典と根拠

ORDレコード
ord-8c5ad24b05b84a5e803288c0514a71c6
出典データセット
uspto-grants-2011_01
特許番号
US07872018B2

反応ノート

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