Chloroacetic Acid → 2-(Chloromethyl)-1-methylbenzimidazole
反応式
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH2:9].[Cl:10][CH2:11][C:12](O)=O>Cl.O.C(=O)(O)[O-].[Na+]>[Cl:10][CH2:11][C:12]1[N:2]([CH3:1])[C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:9]=1参加物
6
反応条件
- 温度
- 55 °C
実験手順
N-methyl-phenylenediamine (1 g, 8.2 mmol) and chloroacetic acid (0.9 g, 9.4 mol) were dissolved in 5 N aqueous hydrochloric acid (10 mL) and stirred at 55° C. overnight. The reaction mixture was then diluted with water and basified with solid sodium bicarbonate to give a precipitate which was filtered, washed with water and dried to provide the desired compound (1.3 g, 87%).
後処理
- customto give a precipitate which
- filtrationwas filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-ba330bcfa33e419daff6496203bb19c7
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07872018B2
反応ノート
読み込み中…