化工社化工社 化学情報印刷レポート · 研究参考用
Sertraline → Sertraline Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sertraline | HCID 68617 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Sertraline Hydrochloride | HCID 63009 | — |
反応手順
Sertraline base (5.8 g) was dissolved in toluene (200 mL). Gaseous hydrochloric acid was bubbled (about pH 1.5) through the solution to induce the formation of sertraline hydrochloride Form XVI. The solution gelled while it was being acidified but remained stirrable. Filtration and drying at 50° C. for 16 hours yields sertraline hydrochloride Form XVI (6.61 gr.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06858652B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-9ee4cd5e050c42d7ab043c502bf67170 |
| 出典メモ | uspto-grants-2005_02 |