反应详情

Sertraline base (5.8 g) was dissolved in toluene (200 mL). Gaseous hydrochloric acid was bubbled (about pH 1.5) through the solution to induce the formation of sertraline hydrochloride Form XVI. The solution gelled while it was being acidified but remained stirrable. Filtration and drying at 50° C. for 16 hours yields sertraline hydrochloride Form XVI (6.61 gr.).

1. customGaseous hydrochloric acid was bubbled (about pH 1.5) through the solution
2. filtrationFiltration
3. customdrying at 50° C. for 16 hours