Tetrahydrofuran → HCID 178527461、化合物

HRID 25358

反応式

HRID 25358 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[Cl:11].O1CCCC1.[F:17][C:18]1[CH:19]=[C:20]([S:24](Cl)(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1>C(N(CC)CC)C>[Cl:11][C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([NH:1][S:24]([C:20]3[CH:21]=[CH:22][CH:23]=[C:18]([F:17])[CH:19]=3)(=[O:26])=[O:25])[CH:3]=2)[NH:7][N:6]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 178507360HCID 178507360、化合物

生成物 1

HCID 178527461HCID 178527461、化合物収率 37.2%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

N-(3-Chloro-1H-indazol-5-yl)-3-fluorobenzenesulfonamide can be obtained as described in Example 1 from 0.18 g of 5-amino-3-chloro-1H-indazole, 20 ml of tetrahydrofuran, 0.25 ml of triethylamine and 0.23 g of 3-fluorobenzenesulfonyl chloride. 0.13 g of N-(3-chloro-1H-indazol-5-yl)-3-fluorobenzenesulfonamide is thus obtained in the form of a yellow foam which decomposes at approximately 80° C. (analysis C13H9ClFN3O2S % calculated: 47.93; H, 2.78; Cl, 10.88; F, 5.83; N, 12.90; O, 9.82; S, 9.84. % found C, 48.11; H, 2.64; F, 5.14; N, 13.14; S, 8.22).

出典と根拠

ORDレコード
ord-84f1951deb144a93ad4d95396efe02fa
出典データセット
uspto-grants-2005_02
特許番号
US06858638B2

関連ノート

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