Methyl iodide → 1-Cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-1-[1-(thiophene-2-carbonyl)-piperidin-4-yl]-urea

HRID 253810

反応式

HRID 253810 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[C:15]([NH:17][C:18]2[S:19][C:20]([S:23][C:24]#N)=[CH:21][N:22]=2)=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].S[CH2:33][C@@H:34]([C@@H:36]([CH2:38][SH:39])O)O.CI>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)[C:15]([NH:17][C:18]2[S:19][C:20]([S:23][CH3:24])=[CH:21][N:22]=2)=[O:16])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3].[CH:26]1([N:14]([CH:11]2[CH2:10][CH2:9][N:8]([C:6]([C:38]3[S:39][CH:33]=[CH:34][CH:36]=3)=[O:5])[CH2:13][CH2:12]2)[C:15]([NH:17][C:18]2[S:19][C:20]([S:23][CH3:24])=[CH:21][N:22]=2)=[O:16])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 439352DithioerythritolHCID 866111884-[1-Cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester

生成物 2

HCID 578838851-Cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-1-[1-(thiophene-2-carbonyl)-piperidin-4-yl]-ureaHCID 866111874-[1-Cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester

実験手順

4-[1-Cyclohexyl-3-(5-methylsulfanyl-thiazol-2-yl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester was prepared as described in general procedure (H) and (I) using 4-[1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester, dithioerythritol and methyl iodide. Removal of the Boc group and N-acylation using thiophene-2 carboxylic acid as described in general procedure (G), steps 3 and 4 gave the title compound.

後処理

  1. customRemoval of the Boc group and N-acylation

出典と根拠

ORDレコード
ord-17af0617063f4d82b0e3f2633a67df23
出典データセット
uspto-grants-2011_01
特許番号
US07872139B2

関連ノート

読み込み中…