Acetonitrile → 4-Pyrimidinecarbonitrile,2-amino-6-(2-furanyl)-5-methyl-

HRID 254169

反応式

HRID 254169 の反応式
Cl[C:2]1[C:7]([CH3:8])=[C:6]([C:9]2[O:10][CH:11]=[CH:12][CH:13]=2)[N:5]=[C:4]([NH2:14])[N:3]=1.[C:15](#[N:17])C>>[NH2:14][C:4]1[N:3]=[C:2]([C:15]#[N:17])[C:7]([CH3:8])=[C:6]([C:9]2[O:10][CH:11]=[CH:12][CH:13]=2)[N:5]=1

参加物

3

反応物 2

HCID 6342AcetonitrileHCID 185072434-Chloro-6-(2-furyl)-5-methylpyrimidine-2-amine

生成物 1

HCID 668471164-Pyrimidinecarbonitrile,2-amino-6-(2-furanyl)-5-methyl-収率 65%

反応条件

温度
140 °C

実験手順

A solution of 4-chloro-6-(2-furyl)-5-methylpyrimidine-2-amine (80 mg, 0.38 mmol) in acetonitrile (4 mL) was treated with polymer supported cyamide (0.636 mg, 1.91 mmol), stirred at 140° C. in the microwave for 30 min, filtered to remove the resin and the filter cake washed with acetonitrile. The filtrate was concentrated in vacuo to give the title compound (50 mg, 65%) as off-white solid; NMR δH (400 MHz, DMSO) 2.48 (3H, s), 6.75 (1H, dd, J 1.7, 3.5 Hz), 7.04 (2H br s), 7.28 (1H, dd, J 0.7, 3.5 Hz) and 8.00 (1H, dd, J 0.7, 1.7 Hz); M/Z 201 (M=H)+; HPLC 1.1 min. (50/80).

後処理

  1. filtrationfiltered
  2. customto remove the resin
  3. washthe filter cake washed with acetonitrile
  4. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-c74d9c1988604ab2acf5b2d783e0e5bb
出典データセット
uspto-grants-2011_01
特許番号
US07875600B2

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