Aluminium lithium hydride → 3-[(4-methylpiperazin-1-yl)methyl]-1H-indole

HRID 254191ノート

反応式

HRID 254191 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=O)=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH3:18][N:15]1[CH2:16][CH2:17][N:12]([CH2:10][C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:13][CH2:14]1

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 21854014HCID 21854014、化合物

生成物 1

HCID 2275843-[(4-methylpiperazin-1-yl)methyl]-1H-indole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

(1H-Indol-3-yl)-(4-methylpiperazin-1-yl)methanone (2.44 g, 0.01 moles) in THF was treated with cooled and stirred suspension of Lithium aluminum hydride (g, 0.011 moles in THF slowly over the period of 2 to 5 hours, the reaction mixture was heated to reflux for 2-4 hours, after the completion of reaction, the reaction mixture was poured on to the ice and the compound was extracted in ethyl acetate. The residue obtained was purified by flash chromatography (silica gel, EtOAc/Hexanes, 2/8) to afford the compound, which was identified by IR, NMR and mass spectral analyses as the title compound.

後処理

  1. temperaturewith cooled
  2. temperaturethe reaction mixture was heated
  3. temperatureto reflux for 2-4 hours
  4. customafter the completion of reaction
  5. extractionthe compound was extracted in ethyl acetate
  6. customThe residue obtained
  7. customwas purified by flash chromatography (silica gel, EtOAc/Hexanes, 2/8)
  8. customto afford the compound, which

出典と根拠

ORDレコード
ord-db9fb9c74c724df1a2c7e0c692015dc6
出典データセット
uspto-grants-2011_01
特許番号
US07875605B2

反応ノート

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