Hydrazine hydrate (1:1) → 5-Bromopyridine-2-carbohydrazide

HRID 254248

反応式

HRID 254248 の反応式
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][N:6]=1)=O.O.[NH2:13][NH2:14]>CO>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]([NH:13][NH2:14])=[O:2])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 7016458Methyl 5-bromopyridine-2-carboxylate2 回

生成物 1

HCID 234679385-Bromopyridine-2-carbohydrazide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-Bromo-pyridine-2-carboxylic acid methyl ester (J. Org. Chem., 2001, 66(2), 605-608, compound 4) (18.10 g, 83 mmol) and hydrazine monohydrate (12.5 mL, 250 mmol) were dissolved in methanol (400 mL) and the reaction mixture heated to reflux for 48 hours. The reaction mixture was then filtered and the precipitate collected dried in vacuo to yield the title product, 15.40 g.

後処理

  1. temperaturethe reaction mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationThe reaction mixture was then filtered
  4. customthe precipitate collected
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-cabaad21c61a4c72b741a6c4de69f450
出典データセット
uspto-grants-2011_01
特許番号
US07875615B2

関連ノート

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