Methanol → 5-(3-Nitrophenyl)oxazole
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=[O:8])([O-:3])=[O:2].S([CH2:22][N+:23]#[C-:24])(C1C=CC(C)=CC=1)(=O)=O.CO>COCCOC>[N+:1]([C:4]1[CH:5]=[C:6]([C:7]2[O:8][CH:24]=[N:23][CH:22]=2)[CH:9]=[CH:10][CH:11]=1)([O-:3])=[O:2]参加物
5
実験手順
2.04 g (13.5 mmol, 1 eq.) of 3-nitrobenzaldehyde, 2.90 g (14.85 mmol, 1.1 eq.) of tosylmethyl isocyanide, 200 mL of MeOH and 200 mL of DME are introduced into a 1 L flask. 25 g of Amberlyst A26 OH— resin are added and the mixture is heated under reflux for 1 hour. The reaction medium is cooled to room temperature, then the resin is filtered over a frit and rinsed with methanol. After concentration to dryness, 2.56 g (yield=100%) of 5-(3-nitrophenyl)oxazole are obtained. The product is used without subsequent purification.
後処理
- addition25 g of Amberlyst A26 OH— resin are added
- temperaturethe mixture is heated
- temperatureunder reflux for 1 hour
- filtrationthe resin is filtered over a frit
- washrinsed with methanol
出典と根拠
- ORDレコード
- ord-78368bd22f1d4db79ea183052dc39db9
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07875609B2
反応ノート
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