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Acetonitrile → HCID 23135106、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(3-Hydroxyphenyl)piperazine | HCID 2736597 | — |
| 反応物 | n-(4-Bromobutyl)-dihydro-2-naphtylcarboxamide | HCID 66852491 | — |
| 生成物 | HCID 23135106 | HCID 23135106 | 54% |
反応手順
A mixture of the bromo adduct E1 (100 mg, 0.32 mmol), of commercial 3-hydroxyphenyl piperazine (57 mg, 0.32 mmol) and triethylamine (0.07 mL, 0.5 mmol) in CH3CN are reluxed during 16 h. The solvent is evaporated and the residue is taken up in CH2Cl2 (15 mL), washed with brine, dried and concentrated. The residue is purified by chromatography eluting with AcOEt:MeOH (9/1) to yield the titled adduct (mp 152° C., 70 mg, 54%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07875617B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-d5c811394752484d9f35c8383a6030e7 |
| 出典メモ | uspto-grants-2011_01 |