Nitric Acid → HCID 14473250、化合物

HRID 254325ノート

反応式

HRID 254325 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][C:9]([F:12])([F:11])[F:10])[CH:3]=1.S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:18]([O-:20])=[O:19])=[C:4]([O:8][C:9]([F:10])([F:11])[F:12])[CH:3]=1

参加物

4

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric Acid2 回HCID 27772861-Fluoro-3-(trifluoromethoxy)benzene

生成物 1

HCID 14473250HCID 14473250、化合物

実験手順

To 1-fluoro-3-trifluoromethoxybenzene (1 mL) was added concentrated sulfuric acid (1 mL) at 0° C. To the cold solution was added dropwise (0.7 mL) of a solution made from concentrated nitric acid (1 mL) and concentrated sulfuric acid (1 mL). The reaction was slowly allowed to warm to room temperature then poured onto ice and extracted with ether. The organic layer was separated and washed with sodium hydroxide 1N, then brined and dried over magnesium sulfate. The solvent was removed under reduce pressure at room temperature. A pale yellow oil (1 g) was recovered and used without further purification.

後処理

  1. additionthen poured onto ice
  2. extractionextracted with ether
  3. customThe organic layer was separated
  4. washwashed with sodium hydroxide 1N
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent was removed
  7. customat room temperature
  8. customA pale yellow oil (1 g) was recovered
  9. customused without further purification

出典と根拠

ORDレコード
ord-ec1bb395d60b45e989a6646a36bd8ca7
出典データセット
uspto-grants-2011_01
特許番号
US07875618B2

反応ノート

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