Sodium Hydroxide → 2-(2,6-diethyl-benzyl)-1H-imidazole

HRID 254529ノート

反応式

HRID 254529 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[CH:11]([C:13]1[NH:14][CH:15]=[CH:16][N:17]=1)O)[CH3:2].[OH-].[Na+]>Cl.[Zn]>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[CH2:11][C:13]1[NH:14][CH:15]=[CH:16][N:17]=1)[CH3:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 58951693(2,6-diethyl-phenyl)-(1H-imidazol-2-yl)-methanol

生成物 1

HCID 247818692-(2,6-diethyl-benzyl)-1H-imidazole

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 313Hydrochloric Acid溶媒

実験手順

To a solution of 90 mg (0.39 mmol) (2,6-diethyl-phenyl)-(1H-imidazol-2-yl)-methanol (Example 96) in 2 ml concentrated aqueous HCl solution were added 500 mg zinc foil and heated to reflux for 20 hours. Then the mixture was cooled to ambient temperature, aqueous sodium hydroxide solution added, the turbid solution filtered and the filtrate extracted with ethyl acetate. The combined extracts were washed with brine, dried over Na2SO4, filtered and evaporated. 2-(2,6-Diethyl-benzyl)-1H-imidazole was obtained as off-white solid: MS (EI): 214.3 (M+.).

後処理

  1. temperatureheated
  2. temperatureto reflux for 20 hours
  3. filtrationthe turbid solution filtered
  4. extractionthe filtrate extracted with ethyl acetate
  5. washThe combined extracts were washed with brine
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-33c18b7f7683461da07fc1f2e92cb67d
出典データセット
uspto-grants-2011_01
特許番号
US07875645B2

反応ノート

読み込み中…