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Methanol → 5-Tert-butyl-3-(cyclobutylmethyl)thiazol-2(3h)-imine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | 5-tert-Butyl-1,3-thiazol-2-amine | HCID 676485 | — |
| 反応物 | (Bromomethyl)cyclobutane | HCID 2734658 | — |
| 生成物 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | 5-Tert-butyl-3-(cyclobutylmethyl)thiazol-2(3h)-imine | HCID 66851503 | 80% |
反応手順
A mixture of Example 74A (1.56 g, 10 mmol) and (bromomethyl)cyclobutane (1.1 mL, 10 mmol) was warmed to 85° C. and was allowed to stir for 18 h. The mixture was cooled to ambient temperature and the crude material was purified via column chromatography (SiO2, 10% MeOH in EtOAc then 9:1:0.1 CH2Cl2: MeOH:NH4OH) to provide the title compound (1.8 g, 80% yield). MS, DCI, m/z 225 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07875640B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-9058f69e45354b43a0bcb006e1d13a07 |
| 出典メモ | uspto-grants-2011_01 |