反应详情

A mixture of Example 74A (1.56 g, 10 mmol) and (bromomethyl)cyclobutane (1.1 mL, 10 mmol) was warmed to 85° C. and was allowed to stir for 18 h. The mixture was cooled to ambient temperature and the crude material was purified via column chromatography (SiO2, 10% MeOH in EtOAc then 9:1:0.1 CH2Cl2: MeOH:NH4OH) to provide the title compound (1.8 g, 80% yield). MS, DCI, m/z 225 (M+H)+.

1. customthe crude material was purified via column chromatography (SiO2, 10% MeOH in EtOAc