3-Amino-5-nitrobenzoic acid → (3-Amino-5-nitrophenyl)methanol

HRID 254942

反応式

HRID 254942 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:5][OH:6])[CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1

参加物

3

反応物 1

HCID 2393423-Amino-5-nitrobenzoic acid

生成物 1

HCID 15540036(3-Amino-5-nitrophenyl)methanol収率 89%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-amino-5-nitrobenzoic acid (1.12 g, 6.16 mmol) in THF (5 mL) was added dropwise a solution of borane tetrahydrofuran complex solution (13.6 mL, 13.6 mmol) at ambient temperature and the mixture was stirred for 90 minutes. The solvent was then evaporated. Aqueous NaOH (15 mL) was added and the resulting mixture was extracted with ether. The ether solution was dried over anhydrous Na2SO4. Evaporation of ether afforded 921 mg of the title compound (89%).

後処理

  1. customThe solvent was then evaporated
  2. additionAqueous NaOH (15 mL) was added
  3. extractionthe resulting mixture was extracted with ether
  4. dry with materialThe ether solution was dried over anhydrous Na2SO4
  5. customEvaporation of ether

出典と根拠

ORDレコード
ord-e35f272e72554c879e05fbbc6fa22fd1
出典データセット
uspto-grants-2011_01
特許番号
US07875728B2

関連ノート

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