Morpholine → 4-(3-Nitrobenzyl)morpholine
反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[CH:4]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.C(N(CC)CC)C>C1COCC1>[N+:9]([C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=1)[CH2:2][N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)([O-:11])=[O:10]参加物
5
実験手順
A solution of 1-bromomethyl-3-nitrobenzene (2.16 g, 10 mmol), morpholine (1.76 g, 20.2 mmol) and triethylamine (1.0 mL) in THF (60 mL) was heated for two hours at 60° C. The solvent was evaporated, water was added and the product was isolated by extraction with ether. The ether extract was dried over Mg2SO4 and the solvent was evaporated. The crystalline residue was used in the next step without further purification. The product, 4-(3-nitrobenzyl)morpholine, was obtained in 94% yield (2.09 g).
後処理
- customThe solvent was evaporated
- additionwater was added
- customthe product was isolated by extraction with ether
- extractionThe ether extract
- dry with materialwas dried over Mg2SO4
- customthe solvent was evaporated
- customThe crystalline residue was used in the next step without further purification
出典と根拠
- ORDレコード
- ord-b9fde5b032db4a4e86c6f0cfbdde9e71
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07875728B2
反応ノート
読み込み中…