Hydrazine hydrate (1:1) → 3-(Morpholin-4-ylmethyl)aniline
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)([O-])=O.O.NN>C1COCC1.C(O)C.[Ni]>[N:8]1([CH2:7][C:6]2[CH:5]=[C:4]([NH2:1])[CH:16]=[CH:15][CH:14]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1参加物
5
実験手順
To a solution of 4-(3-nitrobenzyl)morpholine (2.0 g; 9.0 mmol) in THF/ethanol mixture (1:1, 50 mL) was added a catalytical amount of Raney-Ni and hydrazine hydrate (36.0 mmol) and the mixture was stirred for 15 min at ambient temperature, filtered through a celite pad and the filtrate was evaporated to provide pure 3-morpholin-4-ylmethylphenylamine (2.03 g, 98%).
後処理
- filtrationfiltered through a celite pad
- customthe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-f2459027d6004a26b51c9599b18eba76
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07875728B2
反応ノート
読み込み中…