Sodium Hydroxide → 2-Oxatricyclo[3.3.1.1,3,7]decane-1-carboxylic acid
反応式
C[O:2][C:3]([C:5]12[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[O:6]1)[CH2:12]2)=[O:4].[OH-].[Na+]>CO.O>[C:5]12([C:3]([OH:4])=[O:2])[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[O:6]1)[CH2:12]2参加物
4
実験手順
To a solution of Example 56A (2.5 g, 12.6 mmol) in methanol/water (1:1, 100 mL) was added 5 N aqueous NaOH (3.8 mL, 19 mmol). The mixture was stirred at room temperature for 3 hours and then extracted with methylene chloride to remove unreacted starting material. The aqueous layer was acidified (pH˜2) with 6 N aqueous HCl and then extracted with methylene chloride. The combined acidic extracts were dried (Na2SO4), filtered and concentrated to afford 1.92 g of the title compound. MS (ESI+) m/z 183 (M+H)+.
後処理
- extractionextracted with methylene chloride
- customto remove unreacted
- extractionextracted with methylene chloride
- dry with materialThe combined acidic extracts were dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-93c02e439a494c58b9793dd82f853cac
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07875639B2
反応ノート
読み込み中…