Thiophosgene → [5-(1H-indol-2-yl)-2-methoxy-phenyl]-isothiocyanate

反応式

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[CH:11]=[CH:12][C:13]([O:17][CH3:18])=[C:14]([NH2:16])[CH:15]=1.[C:19](Cl)(Cl)=[S:20]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[CH:11]=[CH:12][C:13]([O:17][CH3:18])=[C:14]([N:16]=[C:19]=[S:20])[CH:15]=1

参加物

反応物 2

HCID 10040Thiophosgene

HCID 99002045-(1H-indol-2-yl)-2-methoxy-phenylamine2 回

生成物 1

HCID 22568433[5-(1H-indol-2-yl)-2-methoxy-phenyl]-isothiocyanate

実験手順

The product from Example 1, 5-(1H-indol-2-yl)-2-methoxy-phenylamine, (4.76 g, 20 mmol) was reacted with thiophosgene (1.9 mL, 25 mmol) according to the procedure for Example 23, Step A, to give [5-(1H-indol-2-yl)-2-methoxy-phenyl]-isothiocyanate (4.55 g), as a black solid.

出典と根拠

ORDレコード: ord-0fec09881fb740ff8ab79f4f7634b1cd
出典データセット: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06858739B2

反応ノート

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