6-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one → 6-Acetyl-2H-1,4-benzoxazin-3(4H)-one
反応式
[C:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][CH2:9][C:10](OCC)=[O:11])=[C:6]([N+:17]([O-])=O)[CH:5]=1)(=[O:3])[CH3:2].COC1C=CC2OCC(=O)NC=2C=1>C(O)(=O)C.[Fe]>[C:1]([C:4]1[CH:16]=[CH:15][C:7]2[O:8][CH2:9][C:10](=[O:11])[NH:17][C:6]=2[CH:5]=1)(=[O:3])[CH3:2]参加物
5
実験手順
Ethyl (4-acetyl-2-nitrophenoxy)acetate (Intermediate 90) was reacted with iron in acetic acid as described for Intermediate 48. The crude product was obtained as an off white solid after work up. Recrystallization with ethyl acetate/methanol afforded the product as a colorless solid in 51% yield.
後処理
- customThe crude product was obtained as an off white solid after work up
- customRecrystallization with ethyl acetate/methanol
出典と根拠
- ORDレコード
- ord-91875a070ac843faa0a2ddd4f5873564
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07875715B2
反応ノート
読み込み中…