4-Methoxy-2-nitrobenzoic acid → 2-Amino-4-methoxybenzoic acid

HRID 255276

反応式

HRID 255276 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([N+:12]([O-])=O)[CH:4]=1>[Pd].CO>[NH2:12][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]

参加物

4

反応物 1

HCID 2886574-Methoxy-2-nitrobenzoic acid

生成物 1

HCID 3510102-Amino-4-methoxybenzoic acid収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

4-Methoxy-2-nitrobenzoic acid (3 g, 16.4 mmol) was hydrogenated over palladium on carbon (10%, 300 mg) in methanol (80 mL) at room temperature and normal pressure for 18 hours. The reaction mixture was filtered through celite and concentrated to dryness under reduce pressure to give 2.50 g (100%) of the product as a colorless solid.

後処理

  1. filtrationThe reaction mixture was filtered through celite and
  2. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-f8f4666ef20642c2a03ae86bb6637376
出典データセット
uspto-grants-2011_01
特許番号
US07875715B2

関連ノート

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