Diethyl Ether → 1-Methyl-2-methoxyethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate

HRID 255488ノート

反応式

HRID 255488 の反応式
[Cl:1][C:2]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([OH:14])=[O:13])[CH:8]=[CH:9][CH:10]=1.[CH3:23][O:24][CH2:25][CH:26](O)[CH3:27].C1(C)C=CC(S(O)(=O)=O)=CC=1.CCOCC>C1C=CC=CC=1>[Cl:1][C:2]1[CH:18]=[C:17]([C:19]([F:21])([F:20])[F:22])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([O:14][CH:26]([CH3:27])[CH2:25][O:24][CH3:23])=[O:13])[CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 6101p-Toluenesulfonic acidHCID 79001-Methoxy-2-propanolHCID 13607437{3-[2-Chloro-4-(trifluoromethyl)phenoxy]phenyl}acetic acid

生成物 1

HCID 138490201-Methyl-2-methoxyethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate収率 97%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

3.3 g of 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetic acid and 1.8 g of 1-methoxy-2-propanol were dissolved in 50 ml of benzene, followed by addition of 0.5 g of p-toluene sulfonic acid. Then, the mixture was heated under reflux for 6 hours. After completion of the reation, 50 ml of ether was added to the reaction mixture. The resulting mixture was washed with water by the customary method and dehydrated with anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain 3.9 g of 1-methyl-2-methoxyethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate.

後処理

  1. temperatureThen, the mixture was heated
  2. temperatureunder reflux for 6 hours
  3. washThe resulting mixture was washed with water by the customary method
  4. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-664edf2ed25e48778f4b59b45357a0b4
出典データセット
uspto-grants-1987_10
特許番号
US04698094

反応ノート

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