Diethyl Ether → Methoxycarbonylmethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate

HRID 255489

反応式

HRID 255489 の反応式
[Cl:1][C:2]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([OH:14])=[O:13])[CH:8]=[CH:9][CH:10]=1.C[CH:24](O)[C:25]([O-:27])=[O:26].[C:29]1(C)C=CC(S(O)(=O)=O)=CC=1.CCOCC>C1C=CC=CC=1>[Cl:1][C:2]1[CH:18]=[C:17]([C:19]([F:21])([F:20])[F:22])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([O:14][CH2:24][C:25]([O:27][CH3:29])=[O:26])=[O:13])[CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 6101p-Toluenesulfonic acidHCID 91435LactateHCID 13607437{3-[2-Chloro-4-(trifluoromethyl)phenoxy]phenyl}acetic acid

生成物 1

HCID 13630152Methoxycarbonylmethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate収率 726.9%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

3.3 g of 3-(2'-chloro-4'-trifluoromethylphenoxy) phenylacetic acid and 1 g of methylglycolate were dissolved in 50 ml of benzene. Then, 0.2 g of p-toluenesulfonic acid was added to the resulting solution, followed by heating under reflux for 3 hours. After completion of the reaction, 50 ml of ether was added. The resulting reaction mixture was washed with water according to the customary method and dehydrated with anhydrous sodium sulfate, and the solvent was distillend off under reduced pressure to obtain 3.4 g of methoxycarbonylmethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate.

後処理

  1. temperatureby heating
  2. temperatureunder reflux for 3 hours
  3. additionwas added
  4. customThe resulting reaction mixture
  5. washwas washed with water according to the customary method

出典と根拠

ORDレコード
ord-ea1321671bf84374b811f91bf6d035e1
出典データセット
uspto-grants-1987_10
特許番号
US04698094

関連ノート

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