Ethyl 6-hydroxy-7-(prop-2-en-1-yl)-1H-indole-2-carboxylate → HCID 20183534、化合物

HRID 255508ノート

反応式

HRID 255508 の反応式
[OH:1][C:2]1[C:10]([CH2:11][CH:12]=[CH2:13])=[C:9]2[C:5]([CH:6]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[NH:8]2)=[CH:4][CH:3]=1>C(O)C.[Pd]>[OH:1][C:2]1[C:10]([CH2:11][CH2:12][CH3:13])=[C:9]2[C:5]([CH:6]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[NH:8]2)=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 13203765Ethyl 6-hydroxy-7-(prop-2-en-1-yl)-1H-indole-2-carboxylate

生成物 1

HCID 20183534HCID 20183534、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The product of step b) was dissolved in dry ethanol (350 ml), treated with 10% Pd/C (0.3 g) and hydrogenated at 35 psi at room temperature until H2 uptake ceased (1.5 hours). The catalyst was filtered off and the filtrate evaporated to dryness.

後処理

  1. custom(1.5 hours)
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated to dryness

出典と根拠

ORDレコード
ord-15372c7080454dc689a6f0ecb4b3b457
出典データセット
uspto-grants-1987_10
特許番号
US04698345

反応ノート

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