HCID 20183595、化合物 → HCID 20183608、化合物

HRID 255560ノート

反応式

HRID 255560 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[CH:14][C:13]=2[N+:22]([O-])=O)=[CH:5][CH:4]=1.[H][H]>C1(C)C=CC=CC=1.[Pt]>[NH2:22][C:13]1[CH:14]=[N:15][C:16]2[C:21]([C:12]=1[NH:11][CH2:10][CH2:9][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=1)=[CH:20][CH:19]=[CH:18][CH:17]=2

参加物

5

反応物 2

HCID 20183595HCID 20183595、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 20183608HCID 20183608、化合物

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 1140Toluene溶媒

実験手順

Using the method of Example 26, 20.4 g (0.063 mole) of 4-[2-(4-methoxyphenyl)ethylamino]-3-nitroquinoline was reduced by hydrogen in 300 ml of toluene with 5% platinum on charcoal. The solvent was then evaporated to provide a residue of 3-amino-4-[2-(4-methoxyphenyl)ethylamino]quinoline. To this residue was added 28 g (0.19 mole) of triethyl orthoformate and the mixture was heated at about 125° C. for two hours. To this mixture was added about 100 ml of aqueous hydrochloric acid and the mixture was heated on a steam bath for thirty minutes. After cooling, the precipitate was separated by filtration, washed sequentially with isopropanol and diethyl ether, and dried. To the solid was added water and ammonium hydroxide, after which the mixture was cooled and the solid was separated by filtration. A portion (3.5 g) of the solid was dissolved in isopropanol, and acidified with hydrochloric acid. The solid was separated by filtration, washed with isopropanol and dried to provide 1-[2-(4-methoxyphenyl)ethyl]-1H-imidazo[4,5-c]quinoline hydrochloride hydrate, m.p. 209°-213° C. Analysis: Calculated for C19H17N3O.HCl.1/3H2O: %C, 66.0; %H, 5.4; %N, 12.2; Found: %C, 66.1; %H, 5.3; %N, 12.3.

後処理

  1. customThe solvent was then evaporated

出典と根拠

ORDレコード
ord-e93a0b0071c944ac9058d34736026049
出典データセット
uspto-grants-1987_10
特許番号
US04698348

反応ノート

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