Ammonia → 4h-Quinolizin-4-one-3-carboxamide

HRID 255595ノート

反応式

HRID 255595 の反応式
[CH:1]1[CH:2]=[C:3]([C:12]([OH:14])=O)[C:4](=[O:11])[N:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.C(N1C=CN=C1)([N:17]1C=CN=C1)=O.N>CN(C)C=O>[CH:1]1[CH:2]=[C:3]([C:12]([NH2:17])=[O:14])[C:4](=[O:11])[N:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2

参加物

5

反応物 3

HCID 222AmmoniaHCID 682631,1'-CarbonyldiimidazoleHCID 15632080HCID 15632080、化合物

生成物 1

HCID 119605794h-Quinolizin-4-one-3-carboxamide収率 85.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

To a suspension of 4H-quinolizin-4-one-3-carboxylic acid (2.27 g) in dry N,N-dimethylformamide (22.7 ml) was added 1,1'-carbonyldiimidazole (2.92 g). The resulting suspension was heated to 100° C. and kept for 30 minutes. After cooling to room temperature the resulting solution was treated with dry ammonia and stirred for 20 minutes. The crystals separated was collected by filtration and washed with water to give 4H-quinolizin-4-one-3-carboxamide (1.94 g). mp. 230°-232° C.

後処理

  1. temperatureAfter cooling to room temperature the resulting solution
  2. customThe crystals separated
  3. filtrationwas collected by filtration
  4. washwashed with water

出典と根拠

ORDレコード
ord-6af7c792e74041599dad84f7e718ff80
出典データセット
uspto-grants-1987_10
特許番号
US04698349

反応ノート

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