Hydrochloric Acid → 4H-quinolizin-4-one-1,3-dicarboxylic acid

HRID 255600ノート

反応式

HRID 255600 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([C:17]([O:19]CC)=[O:18])[C:9](=[O:16])[N:10]2[C:15]=1[CH:14]=[CH:13][CH:12]=[CH:11]2)=[O:5])C.[OH-].[Na+].Cl>CO>[C:6]1([C:4]([OH:5])=[O:3])[CH:7]=[C:8]([C:17]([OH:19])=[O:18])[C:9](=[O:16])[N:10]2[C:15]=1[CH:14]=[CH:13][CH:12]=[CH:11]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 262620Diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate

生成物 1

HCID 139212454H-quinolizin-4-one-1,3-dicarboxylic acid収率 28%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

To a solution of 1,3-diethoxycarbonyl-4H-quinolizin-4-one (896 mg) in methanol (9 ml) was added 6N aqueous sodium hydroxide (2.58 ml) at room temperature and the mixture was heated with reflux for an hour. After cooling to 0° C., the reaction mixture was acidified to pH 2 with 6N hydrochloric acid and the precipitate was filtered and washed with water to give 4H-quinolizin-4-one-1,3-dicarboxylic acid (202 mg).

後処理

  1. temperaturethe mixture was heated
  2. temperaturewith reflux for an hour
  3. filtrationthe precipitate was filtered
  4. washwashed with water

出典と根拠

ORDレコード
ord-93a652526910429c87415cb6447a0262
出典データセット
uspto-grants-1987_10
特許番号
US04698349

反応ノート

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