CO.[OH-].[Na+].[CH:5]1[CH2:10][CH2:9][CH:8]([C:11]2[N:12]([C:22]3[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=3)[CH:13]=[C:14]([C:19](=[O:21])[CH:20]=2)[C:15]([O:17]C)=[O:16])[CH2:7][CH:6]=1>C(O)(=O)C>[CH:5]1[CH2:10][CH2:9][CH:8]([C:11]2[N:12]([C:22]3[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=3)[CH:13]=[C:14]([C:19](=[O:21])[CH:20]=2)[C:15]([OH:17])=[O:16])[CH2:7][CH:6]=1In a mixture consisting of 5 ml of methanol and 5 ml of a 1N aqueous sodium hydroxide solution was dissolved 0.5 g of methyl 6-(cyclohexen-4-yl)-1-(4-hydroxyphenyl)-4-oxo-1,4-dihydronicotinate, and they wre reacted at room temperature for 30 minutes. After completion of the reaction, the reaction mixture was adjusted to a pH of 5.5 with acetic acid, and the precipitated crystals were collected by filtration, washed with 30 ml of water, and dried to obtain 0.35 g of 6-(cyclohexen-4-yl)-1-(4-hydroxyphenyl)-4-oxo-1,4-dihydronicotinic acid having a melting point of 250° C. or more.
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