5-Acetyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine → 6-Methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid

HRID 255732

反応式

HRID 255732 の反応式
[C:1]([C:4]1[C:5]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[CH:18]=2)=[N:6][C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:8][C:9]=1[CH3:10])(=[O:3])C.Br[O-].[Na+].S(=O)(O)[O-:30].[Na+]>O1CCCC1>[CH3:10][C:9]1[N:8]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:6]=[C:5]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[CH:18]=2)[C:4]=1[C:1]([OH:30])=[O:3]

参加物

5

反応物 3

HCID 151474775-Acetyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidineHCID 23665763Sodium BisulfiteHCID 23673712Sodium hypobromite

生成物 1

HCID 151474876-Methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 5-acetyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.5 g), tetrahydrofuran (70 ml), sodium hypobromite (70 ml) was stirred for 2 hours at ambient temperature. To the mixture was added an aqueous sodium bisulfite solution. The mixture was washed with diethyl ether (100 ml) and the aqueous solution was acidified to pH 3.0 with 10% hydrochloric acid. The resultant crystals were collected by filtration to give 0.80 g of 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid.

後処理

  1. washThe mixture was washed with diethyl ether (100 ml)
  2. filtrationThe resultant crystals were collected by filtration

出典と根拠

ORDレコード
ord-19c85a267351462d806f23799a5721f5
出典データセット
uspto-grants-1987_10
特許番号
US04698340

関連ノート

読み込み中…